Kondratska I. Assessment of insulin resistance in subjects with type 2 diabetes mellitus or impaired glucose tolerance with arterial hypertension

Object of study: insulin sensitivity of tissues. The aim of study: evaluate the insulin sensitivity in subjects with type 2 diabetes (DM2) or impaired glucose tolerance (IGT) with arterial hypertension (AH), metabolic syndrome (MS), and optimization the treatment this patients. Methods and equipment: clinical, anthropometrics, biochemical, radioimmunological, immunofermentative, statistical. Analyzer Liviya and Bayer-express-560, Beckman EIA/RIA Gamma5500B, Stat Fax 303+. Theoretical and practical results: The insulin resistance was the most pronounced in the group of patients with AH and dysglycemia. The insulin resistance, lipid levels of plasma, and the levels of IL-6 were significantly increased in patients with MS compared to those without MS. The QUICKI and Matsuda indexes were most informatively in the group of patients with hypertension, and HOMA - in subjects with impaired glucose metabolism.The treatment with imidazoline receptors agonist moxonidine lead to improvement of insulin sensitivity in patients with MS and DM2. Novelty: Patients with the combination of AH and IGT/DM2 have the most pronounced insulin resistance. The patients studied did not receive any medications before the examination. The treatment with imidazoline receptors agonist moxonidine lead to improvement of insulin sensitivity in patients with MS. Moxonidine treatment resulted in reduction of plasma levels of IL-6. Introduction: Results used in diagnostics and treatment in patients with arterial hypertension, DM2, and MS. Field of application: endocrinology, cardiology, therapy.