Dzhandoyeva N. Clinicopathogenetic peculiarities of vascular dementia development

The thesis presents the results of investigating of cliniconeurologic phenomena, cerebral structural changes, cerebral circulatory dynamics, thrombocyte hemostasis, reproductive hormones in patients suffering from vascular dementia, with the objective of working out criteria of diagnosis and prevention and treatment measures. On the basis of the results of clinical, psychodiagnostic, computerized tomographic, dopplerographic and biochemical examination of 97 patients with vascular dementia in age 65-79 have been investigated. The clinical peculiarities, structural changes, cerebral hemodynamic, thrombocyte hemostasis depending upon the type and severity of vascular dementia have been established and analyzed. The results of the research made it possible to work out criteria of diagnosis as well as prevention and treatment measures. Key words: vascular dementia, pathogenetic mechanisms, structural changes of brain, cerebral hemodynamic.