Kolomiytseva G. The improvement of the tactics of the immunization of the measles, epidemic parotitis and rubella of children born by HIV-infected mothers

The dissertation is devoted to study of the epidemiological factors, that define the need of immunization of children born by HIV-infected mothers, against measles, epidemic parotitis, rubella and determination to its safety, immunological and epidemiological efficiency. It is installed that in Donetsk region epidemic spreading of HIV-infections exists on modern stage on the account of the general action of parenteral infection and heterosexual ways of trasfer of the infection. The amount of children born by HIV- infected mothers, increases annually that growing total for 1996-2006 has formed 2908 children. For the two years (2005-2006) the increase of morbidity of measles, epidemic parotits and rubella children at age before 1 and 1-2 years occurs. The share of non immunized of children of the preschool age, with pathology of health particularly increases. Certain safety of immunizations against measles, epidemic parotitis, rubella of children born by HIV-infected mothers, frequency reaction after immunization. It is installed high immunological and epidemiological efficiency of the vaccination against measles, epidemic parotitis, rubella of childre born by HIV-infected mothers. Positive seroconversion is determined from 95,4% children at seronegatives before immunization to virus of the measels, from 86,8% - epidemic parotitis and 95,5% - rubella. The factor to epidemiological effeciency immunization of measles has formed 86,4%, idex to efficiency - 7,3. It is shown the absence of the deterioratio of the factors cellular and humorale section immunity of children, born by HIV-infected mothers, in the process of immunity answer to measles vaccine antigen.