Zhupan B. Role of coenzyme A in pathogenesis of age cataract

Object - senile cataract. Purpose - rising of treatment and prophylaxis effectiveness of senile cataract by pathogenetic substantiation of coenzym A level correction in patients. Methods - ophthalmological, biochemical, statistics; slit lamp, tonometer, Strightlight Meters. For the first time was established that etionine exerts syncataractogenic effect at light cataract modeling, which has been accompanied with increasing of frequency, degree and rate of lenticular opacity. The prevention decrease of coenzym A level in eye blood and tissue has been proved at light cataract modeling by injected preparation, consisting of "Coenzyme- compositum". More marked decrease of coenzym A level in patient's blood, lens and aqueous humor was revealed in case of different cataract types. The principal possibility of stabilization of lens pathology with Coenzym A application is substantiated on the base of clinic and biochemical investigations if patients have arising cataract. The results are adopted at the Filatov Institute, Main Military Clinic Hospital of Ministry of Defence of Ukraine (MD of Ukraine), Kiev Polyclinic N15 MD of Ukraine, Kiev medical-diagnostics Center of MD of Ukraine. The sphere of use - medicine, ophthalmology.