Kishenya M. The role of humoral regulation factors in systemic hemodynamics disoders formation at early period of traumatic disease

Object of the investigation - 258 white rats-males with a trauma by Kennon models in the modification Shtykhno Y.N., 50 control and 10 intact animals; purpose - to establish the pathogenetic role of factors of the humoral regulation in violation of systemic hemodynamics and damage of myocardium in the early period of traumatic disease; to base possible directions of cardioprotective principles; methods: physiological, biochemical, radioimmunological, immunoenzymological, immunohistochemical, statistical; novelty and results - it is first shown that adaptive reaction of sympathoadrenal system is increase it functional activity, which has damage signs and depress cardiovascular system and lethality, if activation is excessive. It was set, that reduction prostacyclin and NO correspond to violations of systemic hemodynamics. Two types of systemic hemodynamics - hypodynamic and decompensated was first shown. Reaction of systemic hemodynamics was estimate as stage. First the role of hymoral mechanisms was determinate at different types of systemic hemodynamics depend from violation stage. The role cardiospecific marker creatine phosphokinase-MV was proved in myocardium damage in traumatic disease. The character and interrelation changes of pro- and antioxidant systems, system of cyclic nucleotides and prostanoids was established at different types of systemic hemodynamics. First NO-system was studied in early period of traumatic disease, was shown the depression of NO synthesis and NO- synthase activity, extension of activity of arginaze mechanism with urine accumulation. The depression of NO synthesis depend from activation of free radical oxidation, intensification of lipoperoxidation and decrease of antioxidant system activity;it was introduced – in scientific work of the Central research laboratory of Donetsk national medical university and department of experimental researches of Institute of urgent and recovery surgery (Donetsk), and also in training course at department of pathological physiologyof Donetsk national medical university, Institute of traumathology and orthopedy (Donetsk); department of anaesthesiology, intensive care and critical state medcine of Donetsk national medical university, department of the general and clinical pathological physiology of Odessa state medical university, departments of pathological physiology of Lugansk state medical university, Bukovina state medical university (Chernovtsy), Crimean state medical university (Simferopol); scope of use - educational proces and scientific work of medical university, diagnostic and medical process of department.