Haiduchok I. Chlamydial infection and immunodeficiency: immunopathogenesis and immunodiagnostics

This thesis is devoted to the studying of the peculiarities of function-structural phagosyte changes due to the hyperimmunocomplex syndrome in the experiment of chlamydial infection with immunodeficiency formation in the course. In conditions of experimental hyperimmunocomplex syndrome there were revealed considerable morpho-functional phagocyte changes, particularly of their reserved possibilities and increase of NO-dependent inducible processes within. Patients with chlamydial infection revealed to have dominating hyperimmonucomplex syndrome that was deepening the phagocyte system changes, immunoregulating factors of immune response and promoted the formation of different types of immunodeficiency in patients with chlamydial infection and deepening the chronicity of the process. Immunodeficiency complicated the course of the chronic chlamydial infection, caused steady changes of immunoresponse of immunoregulating mechanisms and formation of autoimmunoagression. Immunodeficiency diagnostics peculiarities were detected in conditions of chronic chlamydial infection as well as autoimmune complications in these patients.