Vinogradov O. Mechanisms of the development of the venous hyperemia in adenohypophysis at injured pulse pressure in cavernous sinus (experimental research)

The investigation object: hemodynamic in the anterior part of the hypophysis in condition of injured pulse pressure in cavernous sinus. The investigation goal: complex morphofunctional determination of mechanisms of development of the venous hyperemia in adenohypophysis at injured pulse pressure in cavernous sinus. Methods of research: pathophysiological, histological, electronic microscope, stereometric, functional and statistical methods were used in the dissertation. The theoretical and practical importance of the received results: The results of the research increase and improve the basis of mechanisms of blood circulation in the anterior part of hypophysis and determine the main role of pulse of cavernous part of the internal carotid artery in formation of intraorganic blood outflow in norm and for parasellar vascular pathology. The experimental model of change pulse pressure in the cavernous sinus was at first elaborated. The methods of quantitative and graphic determination of parameter of the pulse pressure in the cavernous sinus were also elaborated. The experimental model of morphofunctional complex "Cavernous sinus - internal carotid artery - hypophysis" was proposed. The quantitative analysis of morphofunctional parameters of venous circulation has a practical role. It is the basis for prognosis of disturbances in anterior part of hypophysis for change of pulse pressure in cavernous sinus for atherosclerotic and sclerotic changes in the wall of the internal carotid artery and for parasellar vascular pathology (sinus-thrombosis, stales after scull-brain trauma, parahypophyseal hematoma, adenoma of hypophysis, carotic-cavernous fistula etc.). The scientific novelty of the investigation results: The effect of pulse pressure in cavernous sinus onto blood circulation in the anterior part of hypophysis was studied. It was established that venous hyperemia in the anterior part of hypophysis developed in result of decrease of the pulse pressure in cavernous sinus. The character of changes of morphofunctional indexes of vascular channel of the anterior part of hypophysis connected with change of pulse pressure in cavernous sinus and depend on exposition of experiment. The quality and quantity indexes of pulse pressure in cavernous sinus in norm, in false operated animals and in unilateral change of pulse of intrasinus part of internal carotid artery were determined in the work. The analysis of morphological and morphometric parameters of development and elimination of venous hyperemia in the anterior part of hypophysis in correlation of change of pulse pressure in cavernous sinus was spent. It was reveled that quality and quantity of amount and size of the secretors granules in cells of adenohypophysis were changed in condition of venous hyperemia. The sorption of the cells of different areas of the anterior part of hypophysis increased with different value. It was result of the venous hyperemia, hypoxia and showed on changes of penetration of cells membranes to exogenic substances. The degree of implementation: The results of the research are implemented in practice of experimental medicine at Chairs of pathophysiology of Lugansk and Krym State Medical Universities, Human and Animal Anatomy and Physiology Chair of Lugansk Taras Shevchenko National Pedagogic University. Branch of usage: medicine, pathological physiology, endocrinology, angiology, neurosurgery, gerontology.