Golenya I. Co-ordination compounds of copper(II) and iron(III) with pyridylhydroxamic acids

The thesis is dedicated to study of mono- and polynuclear complexes and co-ordination polymers of copper(II) and iron(III) with new polydentate ligands - pyridylhydroxamic acids. The synthetic methods for 37 novel mono-, bi- and polynuclears co-ordination compounds and co-ordination polymers have been elaborated, their composition and the co-ordination modes of the ligands have been determined. Complex formation of pyridine-2,6-dihydroxamic acid have been studied by means of pH-potentiometry, electronic and EPR-spectroscopy, and ESI mass-spectrometry, stability constants of the formed complex species and their distribution depending on pH have been established. By means of X-ray single crystal analysis the structure of 15 synthesised complex compounds was established, in particular 2 mononuclear and 13 bi- and polynuclear complexes and coordination polymers. Two new co-ordination modes of the hydroxamate groups have been discovered, a new oligomerization motif of the hydroxamate ligands in the presenceof copper(II) ions with formation of unprecedented tetra- and octanuclear structures has been found. The magnetic susceptibility temperature dependence study of the synthesised copper(II) complexes was carried out in the temperature range 1,7-300 К. Pyridine-2-hydroxamic and pyridine-2,6-dihydroxamic acids were found to be efficient reversible competitive inhibitors of the copper-containing enzyme tyrosinase.