Tserkovnyuk R. Pathogenic relationships between parameters of general adaptative reactions and immunity among the participants of Chornobyl NPP accident consequences liquidation with chronic pyelonephritis.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U001242

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

04-03-2008

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

3. By using method of factor analysis it is detected that more 3/4 of variance of information about state of adaptive and defensive mechanisms investigated contingent that contents in 68 variables is condensated in 8 principal components. By using method of discriminant analysis it is shown that distinguishes between types of general adaptative reactions of organism (GARO) are exhaustive explained by 26 parameters (8-of leukocytogramma, 4-of endocrine function, 5-of phagocytic link, 6-of T-link, 2-of killer link and 1 - of B-link of immunity). The result of discriminant analysis gives optimal ranking and quantification of various types GARO. By using method of canonical analysis it is detected that functional state of general endocrine adaptive glands determinates state of leukocytogramma. It is shown that parameters of GARO strongly correlates with parameters of antibacterial defensive systems that reflectes pathogenic relationships between state of adaptation and resistance of organism. The adaptogen effects of balneofactors of spa Truskavets' causes minimization of dysadaptose accompanied favourable changes of metabolic processes conected with functions of antibacterial defensive systems. It is demonstrated that immunomodulating effect of balneotherapy is determinated by its adaptogen effect. The standard balneotherapeutic complex of spa Truskavets' causes "considerable improvement" in 15,7%, "improvement" - in 51,4%, "insignificant improvement" - in 32,9% of patients.

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