Pavlij O. 3. Synthesis, chemical transformations, biological activity of derivatives orto-halogenbenzoic, N-phenylanthranilic acids and 9-aminoacridine

The paper is devoted to the search of new biologically active substances amond orto-halogenbenzoic, N-phenylanthranilic acids and 9-aminoacridine. For the confirmation of the structure, pyrite and reactivity element, IR-, UV-, PMR-, mass-spectral, chromatographic methods of analysis. The alternative ways of synthesis for N-phenylanthranilic acids have been used. The technique of quantitative definition N-phenylanhtranilic of acids substituents by a method of biphase titration in system octanol-water is offered. The constants of speed hydrolyze methylic ethers of 3,5-dinitro-N-phenylanthranilic acids. The pharmacological screening allowed to reveal the compounds with a high biological activity. 4-chlor-N-(4'-carboxyphenyl)anthranilic acid possessing a complex biological action was recommender for profound pre-clinical trials.