Vel'ma V. Phytochemical study of species of Sambucus genus plants and development of medicines on their basis

The dissertation is devoted to study of biologically active substances (BAS) in Sambucus nigra and Sambucus ebulus. The system phytochemical study of vegetative and generative organs of Sambucus nigra and Sambucus ebulus was carried out. The qualitative composition and quantitative contents of the basic groups BAS in flowers, leaves, fruits, barks of Sambucus nigra and flowers, leaves of Sambucus ebulus were investigated. 31 substances were isolated from flowers and leaves of Sambucus nigra and from leaves of Sambucus ebulus and their structures were determined. Umbelliferone, skopoletin, eskuletin, skopolin, skimin, eskulin, myricetin and alantoin were isolated for the first time.The complex method to obtain the infusion from flowers and infusion from leaves of Sambucus nigra was developed; the acute toxicity, anti-inflammatory, hepato-protective and antioxidant activities of these infusions were ascertained.The drafts of ANDs on plant materials "Sambucus nigra leaves", "Infusion of Sambucus nigra flowers", "Infusion of Sambucus nigra leaves" were developed. The draft of specification U 15.8-31757369-001:2006 on special food substance - dietetic additive "Elixirs and Balsams on vegetable extract basis" of trade mark "Vitagren": "Balsam "Vitagren" and "Elixir "Timyanivka" (which have flowers of Sambucus nigra in the consists) - was worked out.