Belaya I. Early diagnostics and treatment of cardiac insufficiency in hypertension with concomitant peptic ulcer of duodenum

The dissertation is devoted to studying clinico-pathogenic peculiarities of early stages of cardiac insufficiency in hypertension with concomitant peptic ulcer of duodenum and it is also devoted to the improvement of therapeutic tactics by means of inclusion of associative pathology combination of angiotensin converting enzyme inhibitor of enalapril and antigomotoxic preparations Cor compositum, Coenzyme compositum and Ubichinon compositum into the complex therapy. Character of metabolic disorders has been established: increasing of atherogenic and lowering of antiatherogenic lipoproteins, increase of lipid hydroperoxide content, increase of pressing prostaglandins and less significant rise of depressive ones; electromotive heart force disorder: increase of ansae R area and decrease of ansae QRS area, deceleration of impulse spreading through the myocardium of the ventricles and increase of angular disjunction QRS-P and QRS-T and diastolic function of the left ventricle. The proposed combination of preparations promoted improvement of biochemical indices: level of antiatherogenic lipoproteins has increased and concentration of proatherogenic lipoproteins has decreased in lowering of the lipid hydroperoxide content, activation of depressive and oppression of pressing prostaglandins has taken place and allowed to influence greatly the hemodynamic and electrophysiologic indices of the heart activity: diastolic function of the left ventricle has improved, electromotive heart force has become normal with achieving regress of symptoms of the heart insufficiency 2-3 days earlier in the comparasion with the basic therapy