Porokhovska N. Membrane Dependant Processes in Myocardium Tissue of Guinea Pigs under the Condition of an Acute Hyperimmune Complex Pathology

The dissertation is dedicated to the researching of morphology and functions of cardiomyocytes under the conditions of acute serum disease. There was prove that trigger mechanism of an injury of cellular membranes of cardiomyocytes is excess of circulating immune complexes of medium and small size. As a result there are an activation of the compliment system and excessive lipid peroxidation. Simultaneously, antioxidant protection is failed. Disorders of a composition of cellular and intracellular membranes of cardiomyocytes are developed leading to alterations in their metabolism end energy supply. There was establish that administration of thiotriazolinum and corvitin significantly reduced both structural and metabolic alterations in myocardium cells. Owing to immunomodulating, antioxidant, and membraneprotecting capacities, as well as a capability of an induction of antioxidant protection these drugs protect membranes of cardiomyocytes against damage and provide normal functional activity.