Savustyanenko A. Effects of autonomic regulation on the intercourse of systemic inflammatory response

Thesis shows theoretical general conclusion and new approach in solving a scientific problem: N-cholinergic pathway of systemic inflammatory response management. 183 rats were used for research. The rats are of Wistar line. Spectral analysis of heart rate variability was used for evaluation of autonomic nervous system condition. Spectrophotometry was used for determination of level of enzyme's intra-tissue activity. It was discovered that highly-resistant animals are characterized by high growth rate of parasympathetic activity in response to pharmacologic stimulation of alpha-adrenoreceptors before the model of systemic inflammatory response is developed. Method of cecum ligation and puncture was applied for development of systemic inflammatory response. Strengthening of both parts of autonomic nervous system's influence was observed during first hours of the experiment in case of systemic inflammatory response development in highly-resistant rats in contrast to those rats who died. It was proved that selective pharmacological stimulation of N-cholinereceptors in terms of syndrome of systemic inflammatory response inhibits activation of lactatdehydrogenase and cathepsin D in every internal organ; it also partially prevents intensification of lipid peroxidation and energization of antiozidant system; improves probability of rat survival. Obtained results can be used for future research and during pathophysiologic education.