Beregulyak O. Clinicopathogenetic aspects of preventing and treating postovariectomic syndrome

Dissertation is dedicated to the elaboration and study of comparative efficacy of the staged method of hormonal therapy and phytotherapy in postcastrative syndrome to adapt successfully hypotalamohypophysial system to the surgical menopause as well as to prevent disorders in the homeostasis, lipid, calcium and phosphorus metabolism, atrophic changes in urogenital tract and octeopenic changes in the bones. The use of conservative hormonal therapy results in three times decrease (by Kupperman index) of early clinical evidences of postcastrative syndrome, prevents urogenital lesions (dynamics of colpocytogram and “vaginal health” index) and octeopenic changes in the bones. However, it causes the marks of hypercoagulation and atherogenic changes in lipidogram. The elaborated method enables to normalize early (psychoemotional and neurovegetative) and distant (urogenital disorders and octeopenic changes in the bone tissue) evidences of postovariectomic syndrome and to influence positively on the hormonal balance, calcium and phosphorus metabolism. No atherogenic influence upon lipidogram or hypercoagulation syndrome are observed while using this method.