Gasanov A. Morbidity, prevalence and natural history of chronic hepatitis in human exposed to low doses of ionizing radiation

Aim of the dissertation is to explore the role of the ionizing radiation exposure in clean-up workers of the Chernobyl accident of 1986-1987 with mean equivalent doses from 0.17 to 0.98 Sv; clean-up workers of 1986-1987 evacuated from the 30-km zone and later exposed during the shiff work with total doses оf 0.23-0.91 Sv; evacuees from Prypyat with doses of 1.4-252 Sv; inhabitans of contaminated territories: zone III-d with mean doses 8,29 mSv, zone IV-d with mean doses 5,09 mSv. At clinical-epidemiological study of dose-dependent increase of chronic hepatitis rates was shown in clean-up workers during the first 5 years after exposure at dose limits of 50-500 mSv and above 500 mSv. Elevated risks of IR were demonstrated in exposed over 400 mSv along with the influence of traditional natural history factors. For the first time a dependence was shown between the dose of exposhure, morbility, natural history and age of patients.