Mihenko B. The multyorgan insufficiency syndrome and its correction in patients with acute extensive peritonitis

Analyzed the results of the surgical treatment of patients with acute extensive peritonitis have been. It was studied the dynamics of intensification of necrosis of mucous membrane of small intestine according to the marker of its affection I-FABP, of liver – L-FABP and of the heart – H-FABP in preoperative period and after the 1, 3, 5, 7 days after the operation. During the experimentally modulated peritonitis on base of estimation of the morphological characteristics of mucous membrane of small intestine, of structure of the liver tissue, lungs, myocardium, kidneys it was shown the stage and speed of development of morphologically-structural changes in organs-„targets”, that are forming the development of syndrome of multyorgan insufficiency: heart, lungs, liver, intestine, kidneys. It was proved, that dysfunction of cardio-vascular system was the starting chain in development of multyorgan insufficiency in patients with acute extensive peritonitis. Under the conditions of acute extensive peritonitisin the experiment and in the clinics the using of emoksypin rather reduces the intensity of currency of capacity renewed glutathione, the activization of antyoxigen ferments. Due to the level of multyorgan insufficiency according to the scale of Bernard G.R. and co-author (1995) and the level of bacterial contamination of abdominal cavity during the operative treatment of patients with acute extensive peritonitis there are proved the directions to the choice of the method intubations of intestine, the programmed laparostomia. Оut kinds of medicamentous correction of syndrome of multyorgan insufficiency during the complex treatments of patients in toxically and terminal stages allowed to reduce the frequency of post-operational complications is worked.