Popova T. Differentiated approach to combined treatment and prevention of inflammatory disease of the cervix in HIV - infected females.

The presented Dissertation is dedicated to the study of risk factors for inflammatory diseases in the cervix in HIV - infected females depending on the vaginal microbiocenosis and HIV disease stage, as well as on the development of differentiated combined patterns of treatment.The risk factors for cervical inflammatory diseases in HIV - positive females were: early sex relationships, the number of sex partners over 5, absence of barrier methods of contraception, presence of STD infection and the time length of HIV infection which was 5 yrs and over. The course of the inflammatory cervical diseases in HIV - positive females was characterized by a lengthy time period, resistance to usual antibacterial therapy schemes, as well as by a tendency to recurrence. HIV - positive females in the III stage of the disease (number of CD4+ lymphocytes < 0,4 x 109 /L) had an improved immune system after the combined treatment with highly effective antiretrovirus preparations. This is an important condition for effective treatment of cervical diseases and prevention of their recurrence.