Atamanyuk D. Synthesis, transformation and biological activity of polycyclic fused systems based on 4-thiazolidones

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U002674

Thesis Registration Form

0408U002674.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

23-05-2008

Specialized Academic Board

Д 35.600.02

Danylo Halytsky Lviv National Medical University

Essay

Object - reactions of heterodyne synthesis, alkylation, acylation, recyclization and "domino"-reactions in synthesis of polycyclic fused systems based on 4-thiazolidones; aim - synthesis of novel polycyclic fused systems based on 4-thiazolidones and search of highly active compounds with antitumor, antioxidant, antihypoxic, antimycobacterial, anticonvulsant and antiviral actions as prototypes of innovative drugs; methods - organic synthesis, spectral analysis methods (NMR-, mass-,chromass-spectroscopies), X-Ray analysis, elemental analysis, traditional and high-throughput pharmacological screening, docking, QSAR-analysis; novelty - the effective new methods of synthesis and chemical modification for polycyclic fused systems based on 4-thiazolidones have been worked out, biological activity of synthesized compounds have been studied and "structure-activity" correlations have been carried out; the outcomes - the row of new perspective highly-active compounds, which possess antitumor, antioxidant, antihypoxic, antimycobacterial, anticonvulsant and antiviral activities has been identified; based on compounds' lipophilicity studies, COMPARE-analysis, docking and QSAR-analysis recommendations for rational design of potential antitumor agents have been proposed; there are introduced into scientific and educational process of National Pharmaceutical University and the program of course "Computer technologies in pharmacy" of Danylo Halytsky LNMU; area - pharmacy.

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Dysertacija--Dodatky.doc

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Dysertacija--Rozdil 2--Tablyci 2.02_2.03.doc

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Dysertacija--Rozdil 2--Tablyci 2.12-2.13.doc

Dysertacija--Rozdil 2--Tablyci 2.14-2.15-2.16.doc

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Dysertacija--Rozdil 3--Tablyci 3.02-3.03.doc

Dysertacija--Rozdil 3--Tablyci 3.04-3.05.doc

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Dysertacija--Rozdil 4--Tablyci 4.05-4.06.doc

Dysertacija--Rozdil 4--Text.doc

Dysertacija--Rozdil 5--Rys 5.2.doc

Dysertacija--Rozdil 5--Tablyci 5.14-5.15.doc

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