Tsykalova V. Lipophylic glycosides of muramyldipeptide: synthesis and antiinfection protective action

Thesis devotes of synthesis of new N-acetylmuramoyl-L-alanyl-D-isoglutamine (muramyldipeptide, MDP) lipophylic glycosides with various structures of aglycone, different types, and configurations of glycoside bond, and establishments of effects of structure and lipophility of MDP glycosides on their protective antiinfection action. Synthesis of new b-glycosides with primary and secondary symmetrical aliphatic, alicyclic, alkylphenyl, alkylphenylthio, 2-(adamantyl-1)- and arylethyl aglycons was accomplished. New lipophilic a-glycosides of muramyldipeptide, namely a-dodecyl, a-(undecyl-6), a-cycldodecyl-MDP were derived. Glycosides of MDP, which stimulation resistance of mouse's in the presence of gram-positive (S. aureus) and gram-negative (Е. coli) bacterium's, were revealed. It was founded that b-decyl-MDP have protective effect against influenza virus infection in mice.