Avramenko I. The role of dysfunction of endothelium in young age children with congenital heart deseases

Early diagnostics of endothelial dysfunction is based on the investigation of the levels of nitrogen oxide and endothelin-1 in the blood serum of the infants with congenital heart anomalies/ Present studies revealed high nitrogen oxide concentrations and low endothelin-1 concentrations in the blood of patients with both type of congenital heart conditions: those with increased and decreased pulmonary circulation. Endothelial dysfunction in patients with congenital heart deseases is noted early, even before manifestation of pulmonary hypertension and histological sings of smooth muscles disoders. It was proved that blood levels of nitrogen oxide and endothelin-1 can be used as diagnostic markers of secondary pulmonary hypertension, which complicates the course of congenital heart anomalies with increased pulmonary circulation. They should be taken into account in determination of pulmonary hypertension severity and in decision making about optimum time for surgical correction.