Grynenko V. Synthesis, physical-chemical and pharmacological properties of the derivatives of 2-hydroxyoxanilic and 2-hydroxymalonic acids

This thesis is dedicated to the search of the new biologically active substances among derivatives of such as 2-hydroxymalonanylic acid and 2- hydroxyoxanilic acid, and to the establishment of conformities of dependence structure-action in the range of the synthesized substances. The methods of synthesis have been elaborated and the range of new derivatives among N-substituted amides and b-N-acylhydrazides 2-hydroxyoxanilic and 2-hydroxymalonic acids have been obtained. The structure of the compounds obtained was proved by methods NMR-, UV- and IR- spectroscopy and their purity and individuality was determined by thin-layer chromatography (TLC). Pharmacological screening for analgesic, anti-inflammatory and anti-oxidative activity has been carried out. By tits results the perspective anti-oxidative substance - 2-chlorobenzylamide- has been chosen for the further investigations. For this substance chemical and physical-chemical methods of identification and assay and tests for purity have been elaborated