Slyvchuk S. Sulfur-containing derivatives of aceto- and acrylonitriles in syntheses of heterocyclic character bioregulators

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U003060

Applicant for

Specialization

  • 02.00.10 - Біоорганічна хімія

20-06-2008

Specialized Academic Board

Д 26.220.01

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine

Essay

Sulfur-containing derivatives of aceto- and acrylonitriles. Research of transformations sulfur-containing derivatives of aceto- and acrylonitriles which conduct to new types functionalized nitrogenous heterocycles, perspective bioregulators. Chemical synthesis, IR-and PMR-spectroscopy, mass-spectrometry, X-ray research. Has been determined that arylthioacetonitriles easily add azidic acid and give correspond substituted tetrazoles, which have transformed to related sulfur-containing tetrazolo[1,5-a]quinolines. It was shown that cyclocondensation products of cyanothioacetamide and amidophenacylating reagents are able to preparation of new 5-acylamino-2-heteryl-1,3-thiazoles series. It was detected that 3-amino-2- arylsulphonylacrylonitriles are very important reagents for preparation of 5-arylsulphonyl-substituted uracyles, 2-thiouracyles and cytozines. Besides that on the basis of available 2-arylsulphonyl- 3-hydrazinoacrylonitriles it had elaborated convenient approach for synthesis of sulfur-containing pyrazolo[1,5-a]pyrimidines. High bioforrence confirmed experimentally. Sphere of use - bioorganic and organic chemistry.

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