Sashchuk N. Age-related aspects of immunologic dysregulation in case of incomplete global cerebral ischemia in male rats

The dissertation deals with the results of investigating the age-related peculiarities of immunological dysregulation which arises in male rats under the influence of incomplete global cerebral ischemia and a possibility of using Emoxipin to correct its manifestations. Incomplete global cerebral ischemia in all the structural-functional zones of the thymus of the animals of both groups has been shown to cause a change of the total density of thymocytes, a redistribution in the lymphoid population structure, change of the morphometric and densitometric parameters of thymocytes. The most sensitive to incomplete global cerebral ischemia is the subcapsular and deep cortical zones of the thymus of the animals of both age groups, whereas the influence of cerebral ischemia on the morphometric parameters of diverse forms of thymocytes is the most essential in the intralobular perivascular spaces of the thymus of the animals of both age groups and the medularry zone of three month old rats. It has been ascertained that throughout postnatal ontogenesis there occurs a change of the priority of different zones of the thymus that contain catecholamines in responding to cerebral ischemia which disturbs the intrathymic interrelations of catecholamine-containing structures. The obtained findings substantiate the expediency of using not only neuroprotective therapy, but immunocorrective one as well under conditions of an ischemic injury of the brain.