Poplonkin Y. Influence of cardiovascular remodeling, endothelial dysfunction on developing of hypertension associated with occlusive brachial artery disease and substantiation of therapy strategy

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U003884

Thesis Registration Form

0408U003884.pdf

Applicant for

Poplonkin Yevgen Ivanovych

Specialization

14.01.11 - Кардіологія

Date of defense

02-07-2008

Specialized Academic Board

Д 17.600.02

Zaporizhzhya State Medical University

Essay

Dissertation is devoted to the study of remodeling features of vessels, endothelial function of arteries and cerebral circulation of blood for patients with hypertension associated with occlusive brachial artery disease and hypertension of the II stage, and also to influence of monotherapy of Spirapril and Lacidipin on processes that were studied. Intercorrelation is set between stage of cerebral perfusion dysfunction, remodeling of arteries and endothelial function of extracranial arteries. Negative influence of endothelium-dependent dysfunction is well-proven vasodilatation of internal carotid arteries on Doppler. It is well-proven that increase of ET-1 concentrations in blood serum of patients with hypertension associated with occlusive artery disease and by making progress decline of FV, which is very important for early diagnostics of disease and correct choice of antihypertension therapy. It is proven that antihypertension medication influence cerebral hemodynamics differently. The medication ofchoice for patients with hypertension associated with occlusive artery disease is Lacidipin, as Spirapril is more effective in patients with hypertension without documented stenosises of internal carotids.

Thesis supervisor

Vizir V.A.

Official opponents

Крайдашенко Олег ВІкторович
Коваль Олена Акіндінівна

Files

aref..doc

e-диссертация--ВВЕДЕНИЕ.doc

e-диссертация--ВИСНОВКИ.doc

e-диссертация--ЗМІСТ.doc

e-диссертация--ПРАКТИЧНІ РЕКОМЕНДАЦІЇ.doc

e-диссертация--РАЗДЕЛ_1.doc

e-диссертация--РАЗДЕЛ_2.doc

e-диссертация--РАЗДЕЛ_3.doc

e-диссертация--РАЗДЕЛ_4.doc

e-диссертация--РАЗДЕЛ_5.doc

e-диссертация--РАЗДЕЛ_6.doc

e-диссертация--СПИСОК УМОВНИХ СКОРОЧЕНЬ.doc

e-диссертация--Список использованной литературы.doc

e-диссертация--ТИТУЛЬНЫЙ ЛИСТ_УКР.doc

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