Apykhtina O. Disorders of nitrogen oxide metabolism in lead vasotoxic action and search for new means of intoxication prevention

Theoretical generalization and results of experimental studies of the actual scientific problem - determination of the part of lead in the pathogenesis of the cardio-vascular pathology and search for new means of biological prevention of intoxications - are laid down in the work. Basing on results of experimental studies, on the background of development of lead intoxication in the tested animals, signs of vasotoxic lead intoxication have been found and involvement of disorders of nitric oxide metabolism have been proved. Additional pathogenetically grounded criteria of their diagnostics have been proposed. The use of glutargin and S. coronata extract in experimental animals on the background of lead acetate exposure promotes the decrease of the level of this metal in biological media, decrease manifestations of its hematotoxic action, improvement of indices of products of reactive oxygen species and nitric oxide metabolism, level of thiol compounds and the shortening function of vessel walls, showingtheir high efficiency and perspective of their use as means of biological prevention.