Missaoui Н. Post infraction remodelling of the myocardium and hypertention: role of biomarkers

TThe dissertation deals with the study of the role of biomarkers (troponin I, C-reactive protein, testosterone) in the clinical picture of acute myocardial infraction (AMI), depending on age (younger/older than 55 years of age), the processeses of remodelling the left ventricle in patients who have endured AMI, and treatment optimization by adding inhibitor 5- quercetin lipoxygenase (corvitin) to the basic course of treatment. A reliable predomination of troponin I (p>0,05), in the patients of the older age group according to the age division - younger/older than 55 years has been established. The positive dynamics of the global ejection fraction in the younger age group at the stage of one month course of treatment (p< 0,001) has been proved versus the older age group with a decrease of testosterone. It has been established that concentric remodelling (87,1%) is observed more often in patients who have suffered from acute myocardial infraction, whereas concentric hypertrophy of the left ventricle isless common (10,6%). A normal geometry of the left ventricle was observed in 2,4 %. An advantage of additional administration of corvitin (a cardioprotectant) has been corroborated in the treatment of patients with AMI over basic antiischemic therapy in the form of optimizing central hemodynamics at the expense of a more essential decrease of troponin I, C-reactive protein without an influence on the androgenous constituent part – with an unauthentic increase of testosterone.