Research objects are patients with acute leucosis and lymphogranulomatosis, which got anthracycline antibiotics and rats with the experimental model of anthracyclinic cardiomyopathy. Purpose - to define features of structurally functional changes of vessels under act of different cumulative doses of anthracycline antibiotics, to develop facilities of their correction for the decline of frequency and weight of anthracycline antibiotics defeats of the cardiovascular system. Methods - clinical, electrophysiological, ultrasonic, biochemical, morphological, statistical. Novelty - for the first time was determined role of structure functional changes of vessels in pathogenesis of forming of anthracyclinic cardiomyopathy, there was analysed intercommunication between the indexes of activity of lipid peroxidation, modeling of vessels and painless myocardial ischemia, was determined morphological changes in coronal arteries for experimental animals under action of different cumulative doses of anthracycline antibiotics. Pathogenetic explanation of carvedilolum indication was given and the methods of prophylaxis of cardiotoxic and poisonous action on vessels of cytostatic drugs were developed on the basis of study of carvedilolum influence on the vascular wall condition, endothelium function, bioelectric activity of myocardium, and also to activity of lipid peroxidation and antioxidant system. Results - there were determined that anthracycline antibiotics have toxic influence on vessels even in small cumulative doses. For patients who got the small cumulative doses of anthracycline antibiotics, observed hyperproduction of nitrogen oxide, and on a background the use of high doses, its synthesis is depressed. There is activating of processes of lipid peroxidation under action of anthracycline antibiotics. Anthracycline derivatives cause development of tachycardia and painless depression of ST segment. Morphological changes, conditioned cardiotoxic influence of anthracycline antibiotics showed by the spasm of arteries,plethora of veins and capillaries with the origin of diapedetic haemorrhage, adhesion-fenomena. Carvedilolum substantially diminishes degree of vessels affection at application of anthracycline antibiotics, reduces activity of lipid peroxidation and in assist in removal of myocardial ischemia. It was introduced in practice of haematological department and treatment-diagnostical center of medical rehabilitation of Institute of urgent and restoration surgery name after V.K. Gusak Academy of Medical Sciences Ukraine, haematological department of Donetsk city hospital №18, therapeutic department of Makeevka city hospital №1 of the Donetsk area, and also in a pedagogical process Donetsk, Kharkov and Lvov state medical university. Branch of useing is a treatment-diagnostical process of cardiologic, haematological and oncologic departments, pedagogical process of therapeutic departments of medical educational schools.
