Voskoboynik A. Synthesis, physico-chemical and biological properties of [{2-R-(3Н)-qunazoline-4-ylіdene}hydrazono]carboxylic acids

Object - (2-R-quinazoline-4-yliden)hydrazines, [{2-R-(3Н)-qunazoline-4-ylіdene}hydrazono]carboxylic acids and their derivatives, 3-(2-aminophenyl)-1,2,4-triazine-5(4Н)-ones; methods - synthesis, IR-, NMR-, mas-, chromato-mass-spectroscopies, X-ray analysis, pharmacological screening; novelty - the preparative methods of synthesis were developed and series of new [{2-R-(3Н)-qunazoline-4-ylіdene}hydrazono]carboxylic acids and their derivatives were obtained, proved that 6-R-3-(2-aminophenyl)-1,2,4-triazin-5(4Н)-ones useable as effective reagents in organic synthesis for 1,2,4-triazino[2,3-с]quinazoline systems formation. Pharmacological screening of antiradical, antioxidant, antiamnestic, antifungal, antibacterial and anticancer activity; the outcomes - are introduced into scientific and educational process of pharmaceutical chemistry, organic chemistry departments of National Pharmaceutical University, pharmaceutical, organic and bioorganic chemistry department of L'viv National Medical University, pharmaceutical chemistry and pharmacology department of Ternopol' State Medical University; area - pharmacy.