Batura I. Exogenous hydrocortisone influence on growth, structure and regeneration of the femur of different age rats

The data of experimental research of the morphological features of growth, structure and regeneration of the femur rat under the influence of exogenous hydrocortisone were pre-sented in this thesis. It was found out that glucocorticoid-induced osteoporosis at 3 and 6 month old rats led to the de-layed longitudinal growth of femur, but decreased transversal growth of femur was shown at 3 month old rats only. This features were caused by periosteal end enchondral osteogene-sis inhibition. It was proved that bone tissue destruction was realized by osteocyte osteolysis and sinuses. The intensity of the bone destructive changes increased with extension of hor-mone dose at animals which were at the stage of active skeleton growth especially. It was identified that a long-term introduction of hydrocortisone (0.5 and 5 mg) reduced osteo-repair process in the rat femur defects. Maximum demonstra-tion was seen in the 3month old animals. The ratio of the cells participating in bone repair was broken.. Processesof regen-erate mineralization and remodeling were slowed down at the late stages of repair osteogenesis.