Kryuk O. Hypermetabolism pathogenesis features in systemic inflammatory response in heavy mechanical trauma

A research object - is the state of hypermetabolism at a system inflammatory response to a heavy mechanical trauma; purpose - determination of the hypermetabolic reaction's mechanism according to the level of proinflammatory cytokines, etiologic structure and severity of bacterial sepsis and establishment of prognosis of hypermetabolism at a heavy mechanical trauma and shock; methods - pathogenetical, physiological, biochemical, immunological, bacteriological, statistical; novelty and results - the novelty of work consists in deepening of theoretical bases of conception of traumatic illness, in particular in clarification of role of gluconeogenesis, as limiting link of hypermetabolism in pathogenesis of heavy posttraumatic reaction; a most value here has circumstance that early lethality of animals in the mortal shock type of posttraumatic reaction is conditioned the decline of efficiency of gluconeogenesis; in establishing a connection of the hyperreactive state of the immune system with hypermetabolism, bacteriemia and sepsis; it is showed that in sepsis pathogenisys autoflora takes part, that colonizes opened biocenosis of organism; at the shock types of posttraumatic reaction (shock to mortal and non mortal) there is transformation of generalized inflammatory reaction into sepsis; it is inculcated in the treatment process of Institute of traumatology and orthopaedy of Donetsk National Medical University, and also in a pedagogical process at Donetsk, Zaporozhia, Crimean, Kharkov, Lugansk medical universities and Dnepropetrovsk medical academy; sphere of use - medicine (pathological physiology).