Garbuzov D. Peculiarities of clinical picture, diagnostics and therapy of a mixed candida-herpetic urogenital infection

Dissertation is devoted to the questions of scientific justification of approaches to increase of efficacy of treatment of patients with a combined candida-herpetic infection. There are presented the data on clinical-anamnestic peculiarities, etiologic factors of inflammatory process, attendant pathology, modern diagnostic methods of 120 females with urogenital candidiosis. In 90 females herpetic viral infection was timely diagnosed, as a group of comparison there were examined 30 patients who had only herpetic infection. In the dynamics of observation there was defined state of non-specific defense factors, neutrophil activity, findings of cell and humoral immunity as well a level of tumor necrosis factor-alfa, alfa-interferon, sIgA in the blood and vaginal discharge, differential findings to administer therapy by means of comparative analysis of clinical peculiarities, course of a disease, etiologic factors and state of immune status, distinguishing therewith different levels of clinical-laboratory disorders in patients. According to revealed levels of clinical-laboratory disorders we grouped patients with mixed infection in definite clinical-therapeutic groups and developed procedure of individualized complex therapy with differential administration of specific methods, pathogenetic agents and topical medicinal forms. In the absence of complications and unfavorable effects in the group of patients under observation this allowed to obtain a marked therapeutic effect, to reduce both the number of relapses of herpetic-viral infection by 2,1 times and their period from 6,7 days to 3,3 days; during a year, to achieve clinical-laboratory recovery from candidiosis in 86,9% of patients, to shorten a number of relapses by 3,2 times.