Shchepansky F. Role of peroxidant-antioxidant proceses dis turbances – in experimental allergis alveolitis pathogenesis, and their correction

The dissertation work is devoted to the study of pecularities of functional condition of cell and humoral chains of immune system and also of prooxidant-antioxidant system – of Allergic alveolitis pathogenesis, depending on periods of development of the disease and sex of animals, use of alpha-tokoferol acetate for complex therapy of patients with exogenic Allergic Alveolitis. It was estimated that in condition of experimental Allergic Alveolitis development – the AOS ferments activity begins to decrease most rapidly in lung tissue on the 40-th day, at the same time these indexes are located at the level of control values in, liver, and the were increased in blood, and on the 60-th day of disease – they were sharply lowered in all marked tissues with prevailence – in lungs. It was proved, that the experimental Allergic Alveolitis is accompanied by gradual activisation of peroxide oxidation processes on 30-40-th day, reaching the highest amount on the 60-th day of disease. These processes were more, expressed in females than in males. The active participation of T and B-immunity systems in mechanisms of Allergic Alveolitis development – was established. The presence of immunocomplex mechanism of tissues’ injury was proved. The correcting influence of antioxidant of Alpha-tocoferol acetate on disturbed functional condition of prooxidant-antioxidant system in Allergic Alveolitis in blood, lung tissue, and in liver tissues.