Lebedeva T. The influence of precursors and blokators of nitric oxide synthesis on metabolic processes in the case of the adrenaline injury of myocardium in an experiment.

The injection of the nitric oxide precursor L-arginine to white sexual-mature male rats with acute adrenaline injury of myocardium is followed by the increase of the nitrite-anion level in the heart, the suppression of the lipid peroxidation intensity, the renewal of activity of the antioxidant system with simultaneous activation of energy-providing processes in the mitochondrias. The analogous, but more positive changes occur in the case of administration of glutargine (the arginine-containing medicine). Opposite, the injection of nonselective NO-synthase inhibitor N-nitro-L-arginine and iNOS selective inhibitor aminoguanidine potentiates the injury of myocardium. The present results demonstrate that L-arginine and glutargine prevent the heart injury associated with myocardial ischemia and hypoxia. It shows itself also in the positive dynamics of ECG and the rising tolerance to the physical loading. The рrotective action of glutargine in acute hypoxia of myocardium is related to some extent to its ability to stimulate nitric oxide synthesis. Such a conclusion has been supported by the results of combined injections of NO-synthase inhibitors with glutargine before the myocardial injury, which led subsequently to the diminishing of the protective effect of glutargine.