Siritsa G. State of vaccine-induced immunity to measles among children and adolescents with different manifestations of tuberculosis infection

The dissertation is devoted to study of tuberculosis influence on state of artificial active immunity to measles. The object of the study is improvement of specific measles prevention in epidemic situation of tuberculosis.Pronounced tendency of increased incidence of tuberculosis among the population and substantial spread of latent tubercular infection were observed among children and adolescents. The early stage of development of non-complicated tubercular infection (latent tubercular infection and local forms of tuberculosis) in children and adolescents was shown to save the protective level of antibodies to measles virus, regardless of terms of the last inoculation with live measles vaccine. Considerable (р ? 0.05) decrease of immunity stress to measles in children with tubercular infection after the course of chemotherapy (chemoprophylaxis), causing increased risk of measles morbidity in this contingent was noticed. To optimize prophylaxis of measles in children and adolescents with tubercular infection, the vaccination is recommended to be done not sooner than a month after the end of the course of chemotherapy (chemoprophylaxis), and not later than a month prior to the beginning of the antirecurrent course of chemotherapy (refresher course of antirecurrent or preventive treatment). Thus, the considerable spread of latent tubercular infection is proved to cause high percentage of children and adolescents receiving chemoprophylaxis, which hinders forming of sufficient measles immune contingent.