Savytska K. Peculiarities of Gastroduodenal pathology in children of preschool primary school age.

Object of the study: gastroduodenal pathology of the preschool and primary school age children. Purpose of the study: to improve the diagnosis and treatment effectiveness of the gastroduodenal pathology of the preschool and primary school age children by researching the clinical course peculiarities at these age periods, using non- invasive diagnosis verification methods and applying the medical product ?-3 polyunsaturated fatty acids (PUFA) in complex therapy. Methods of the study: general clinical, laboratory, instrumental, morphologic, analytic. Theoretical and practical results: the diagnostic criteria, which were devised during researches, permit to expose the gastroduo-denal pathology of the preschool and primary school age children in case of outpatient observation and give a possibility to begin treating the diseases earlier. In some cases, the using of the contact liquid-crystalline thermography method in combination with urea breath HELIK-test, permits to renounce the invasive examination methods for diagnosis confirming and Helicobacter pylori detecting. Using Ukrainian medical product ?-3 polyunsaturated fatty acids allow reducing inflammatory activity and improving repair processes of stomach and duodenum mucous layers and eliminate clinical gastroduodenal pathology symptoms. Novelty: for the first time it was grounded the expedience of the medical product ?-3 polyunsaturated fatty acids using for gastroduodenal pathology therapy of the preschool and primary school age children. This was based on ?-3 PUFA influence on the disease clinical course, and stomach mucous morphologic parameters. The improved non-invasive diagnostic criteria permit to detect with high probability the children Helicobacter pylori-associated pathology and renounce the invasive examination methods for diagnosis confirming. It was obtained, that main sub-jective and objective manifestations of functional and organic gastroduodenal zone affections of the preschool and primary school age children don’t have significant reliable distinctions. It was perfected the urea breath HELIK-test technique and grounded using for Helicobacter pylori-associated pathology diagnostics. This method is of great diagnostic value (sensitivity, specificity, prediction value and precision index) in comparison with HELPIL-test. It was demonstrated that non-invasive Helicobacter pylorus gene detection in biosubstrate (saliva, buccal epithelium, coprofiltrate) is no effective, that permits to renounce the PCR-method of Helicobacter pylori diagnostics in these biomediums. Degree of introduction: the thesis results were put into the practi-cal work of the Kharkiv municipal gastroenterologic center mu-nicipal pediatric clinic №19, Uzgorod municipal pediatric clinic, Sumy regional pediatric clinic and into the educational process of the pediatric gastroenterology and nutriciology department of Kharkiv medical post graduated studies academy, Ministry of Health of Ukraine. There are all necessary documents confirming it. Sphere of application: medicine, paediatrics.