Lupyr M. The role of tissue basophils in cellular reac-tions at chronic inflammation

The investigation object: mechanism of chronic inflammation. The investigation goal: the role of tissue baso-phils (TB) in cellular reactions at chronic inflamma-tion.Methods of research: Pathophysiological, cyto-morphological, histological, histochemical, cyto-chemical, pharmacological and statistical methods were used in the work.The theoretical and practical importance of the received results: The regularities of the changes in the morphofunctional state of focal TB which suggest the role of TB in the pathogenesis of chronic inflamma-tion were established in the detailed dynamics of the process. The phases of TB reaction were revealed and described as to the time and intensity. The role of TB in the focus of chronic inflam-mation in local cellular reactions and reactions of the blood system was shown. It was determined, that TB promote vascular-exudative-infiltrative and reparative phenomena simultaneously limiting accumulation of lymphocytes in the focus, hemopoieses, especially lymphopoiesis andincreasing exit of lymphocytes from the bone marrow to the blood and, thus, control-ling the progression of chronic inflammation. It was determined, that not only focal TB but the whole mast-cell system play the role in the reac-tions of the blood system at chronic inflammation and TB outside the focus also stimulate progression of chronic inflammation and play a com¬pensation role at insufficiency of TB in the focus.A degree of inplementation: the results are im-plemented in an educational process on the depart-ments of pathological physiology of the Kharkiv, Do-netsk, Crimean, Lugansk medical universities, Sumu State University and Ukrainian Medical Stomatology Academy (Poltava). Using Sphere: medicine, biology, patholo¬gical phisiology.