Silina N. The role of the endothelian dysfunction in the development of preeclampsia at pregnant women with arterial hypertension

In work the theoretical substantiation of the role of the endothelian dysfunction in the development of complications of pregnancy is presented, also had been found the earlier (preclinical) criteria of the preeclampsia at pregnant women with primary arterial hypertension and at pregnant women with heavy preeclampsia or eclampsia in the anamnesis. For the first time on the basis of profound research data concerning markers of the endothelian dysfunction (endothelin 1, Willybrand's factor, endothelium-depended vasodilatation) at pregnant women with high risk of development of preeclampsia are obtained and their role in occurrence of this complication is defined. By means of ultrasonic Doppler measurements are studied features of maternal-placental-fetal blood circulation at pregnant women with primary arterial hypertension and at pregnant women with heavy preeclampsia or eclampsia in the anamnesis, that has allowed to develop criteria of early diagnostics of infringements of feto-placentary blood circulation and to define prognostic criteria concerning the possibility of the development of preeclampsia at these pregnant women. It is established, that pregnant women with primary arterial hypertension and pregnant women with heavy preeclampsia or eclampsia in the anamnesis are concerned to be at risk group on development in them of these complications, one of the reasons of this is dysfunction of endothelian system. It is proved, that pregnant women with primary arterial hypertension and pregnant women with heavy preeclampsia or eclampsia in the anamnesis have decrease of endothelium-depended vasodilatation against the increase of level endothelin 1, Willybrand's factor, and decrease in concentration of the placental lactogen and estriol.