Lavrenko G. Cerebral hemodynamics under the influence of phosphene-electrostimulation in disfunctions of the visual analyzer

The thesis studies the influence of phosphen-electrostimulation on hemodynamics in patients with pathologic function of different levels of the visual analyzer - uncomplicated by myopia, with partial atrophy of the optic nerve and amblyopia that are accompanied by disregulation of tonic properties of the cerebral vessels and disorders of pulse volume of the brain. It is shown that electrostimulation of the retina and optic nerve by pulse current which causes the phosphen-phenomenon - phosphen-electrostimulation (PhES), normalizes the pulse volume of the cerebral vessels in persons with chronic decreased visual afferentation due to reduced influence of this medical method on the constrict properties of the cerebral vessels under the condition of different intensity of afferent currrents to the visual analyzer. There was proved dilation of the arteries, arterioles, precapillaries in the basins of the internal carotid and vertebral arteries as well as activation of the venous flow-out from the cerebral region. There was determined dependence of the PhES effect on the time of action of the stimulus. The work also investigated vagotonic PhES effect on the activity of the cardiovascular system. Reconstruction of the cardiovascular system was caused by excitation of the vegetative centres of the central nervous system by the adequate stimulus. There was proved the effect of electrostimulation with PhES parameters on the neurosecretory activity of the magnocellular cells of the supraoptical nucleus of the anterior hypothalamus in rabbits; it shows participation of the neurohumoral mechanism in realization of the reduced vasoactive PhES effect.