Fominova N. Optimization of diagnostics, treatment and prognosis of a cerebral ischemic stroke in the acute period

The dissertation contains data about changes of interdependent clinical-neurological indica-tors, parameters of blood gas structure, oxidant and antioxidant systems, coagulation's and thrombocyte's homeostasis, bioelectric activity of a brain in dynamics of medicaments correc-tions. The work's purpose - to study dynamics of clinical-neurological, biochemical and tool indi-cators changes at patients with arterio-thrombotic and cardio-embolic ischemic stroke in the acute period, on their basis to improve ways of diagnostics, treatment and prognosis of disease for im-provement of direct results. 115 patients with ischemic stroke (IS) were complex inspected in the acute period. The cor-related anamnesis has shown, that criteria of the adverse prognosis of IS were: increasing of oxi-dant's and decreasing of antioxidant's systems; increasing of viscosity of blood against hyperco-agulation; hypostasis of a brain with increase intracranial pressure; signs remaining occlusion in-tracranial arteries at ultrasonic dopplerography; dopplerography an indicator Owershoot factor <1,2, decrease linear speed of a blood-groove below 34 sm/sek; presence vascular contrast at magnet resonant angiography, revealed by suggested method "The Ways of prognosis of an ischemic stroke in the acute period"; presence of the centers of defeat of a brain volume more 95 сm3. These changes were depended on disease severity level. On the basis of the received data new ways of diagnostics and treatment of such illnesses (6 inventions) are suggested and introduced in practice. Intravenous (intra-arterial introduction and in thick intestines oxygenic perphtoran, intravenous introduction reamberin and L-lizin esce-natum, inhalation and thick intestinal oxygenotherapy against traditional treatment lead to authen-tic and faster recourse of neurological deficiency, decrease in quantity of complications on 17,3 %, lethal outcomes - on 8 %. The received results allow expanding diagnostic and therapeutic potential at treatment sick of an ischemic stroke in the acute period. Key words: athero-trombotic, cardioembolic, an ischemic stroke, the acute period, diagnos-tics, prognosis, treatment.