Voloshina T. The period of pregnancy, deliveries and neonatal state in women with chronic inflammatory diseases of kidneys on the background of increased level of the antiphospholipid antibodies.

The thesis covers the issues of the period of pregnancy, deliveries and neonatal state in women with chronic inflammatory diseases of kidneys on the background of increased level of the antiphospholipid antibodies (APA) and optimization of the antenatal monitoring of these women. In women with CG and increased level of APA we often observed the complicated period of pregnancy and deliveries. The indices in the group with the high level of antibodies are more worse, than in the group with their low level: threatened abortion - in PS more, than 10 Units - 55,6 %, in PS, lower, than 10 Units - 37,5 %, in PE more, than 10 Units - 70 %, in PE, lower, than 9 Units - 16,7 %; incidence of preeclampsia - in PS more, than 10 Units - 55 %, in PS, lower, than 10 Units - 12,5 %, in PE more, than 9 Units - 50 %, and in PE, lower, than 9 Units - 16,7 %. In women with CP and increased level of APA, the period of pregnancy was complicated by threathened abortion after 20 weeks (in case of increase of CL and PS), preeclampsia (in case of increased CL level). In newborns from patients with CG and CP and increased level of APA the tendency of weight decrease and low Apgar score was revealed. In pregnant with CP and increased level of APA was revealed the hyperestrogeny in the II trimester, decrease of estriol an progesterone level in III trimester. In pregnant with CG and increased level of PS was revealed the decrease of estradiol level in II trimester, progesterone - in III trimester. The maximum influence of uterine-placental, fetal and kidneys blood circulation in women with CG an CP has increased PS level. The optimization of antenatal monitoring in pregnant with CP, CG and increased APA level promoted the reduction of obstetric complications.