Object of the study: clinical and immunologic adaptation state of children who had lues preventive treatment. Purpose of the study: improving the curative and prophylactic measure effectiveness, early diagnostic perfection of clinical and immunologic disorders problems for children who had lues preventive treatment by the determination of clinical and immunologic adaptation features during neonatal period. Methods of the study: clinical, anamnesis', anthropometric, laboratory, immunologic, serologic, instrumental, sociologic, statistic. Theoretical and practical results: the thesis is devoted to improving the curative and prophylactic measure effectiveness, early diagnostic perfection of clinical and immunologic disorders problems for children who had lues preventive treatment by the determination of clinical and immunologic adaptation features during neonatal period. It is determined that children without specific clinical and serologic early congenital lues marks have clinical course features of neonatal period, immunologic reactivity, health state, physical development peculiarities during the first three years of life. It is elicited the cell-mediated, humoral immunity and cytokine production features. The scientifically grounded mathematical model for individual prognosis of the heightened acute respiratory viral infection morbidity level during the first three years of life was devised. It was based on the distinctive adaptation criteria. For the first time it was exposed the connection of the infant period course and the psychological style of the pregnancy feeling. It was proposed the subsequent tactics for children who had lues preventive treatment, including individual schemes of observation and sanitation and parents special consultation. Novelty: for the first time it was grounded, that newborns without specific clinical and serologic early congenital lues marks have clinical course features of neonatal period: perinatal hypoxic-ischemic encephalopathic, intrauterine growth retardation, prolonged physiologic jaundice, undifferentiated connective tissue dysplasia features prevalence. It was exposed the connection of the infant period course and the psychological style of the pregnancy feeling. It was determined the health state, physical development peculiarities during the first three years of life: physical and mental development delay, the heightened acute respiratory viral infection morbidity level, iron deficiency anemia, allergic, purulent-inflammatory disorders and encephalopathy prevalence. It was elicited the cell-mediated, humoral immunity and cytokine production features during the neonatal period that permitted to determine and systematize clinical and immunologic distinctive disadaptation criteria. It was determined the health state disorder prediction criteria and it was proposed the subsequent tactics for children who had lues preventive treatment. Degree of introduction: the thesis results were put into the practical work of the Kharkiv maternity house № 2, the Kharkiv regional obstetric clinic with neonatal hospital and into the educational process of the common practice - family medicine department of Kharkiv national medical university, Ministry of Health of Ukraine and the neonatology department of Kharkiv medical post graduated studies academy, Ministry of Health of Ukraine. There are all necessary documents confirming it. Sphere of application: medicine, pediatrics.
