Vygivs'ka L. Prognosis, prophylaxis and treatment of preeclampsia in risk-group pregnant women.

Object of the study: preeclampsia in the risk group pregnant women. Purpose of the study: improvement of the methods of prognosticating, preventing and treating preeclampsia in the risk group pregnant women with regard for homeostatic and microhaemodynamic disturbances, thereby contributing to a decrease in the indices of perinatal morbidity and lethality. Methods of the investigation: general clinical, laboratory, statistical ones, echographical and dopplerometrical scanning. Theoretical and practical results: on the basis of the conducted researches, peculiarities were revealed in the course of preeclampsia in pregnant women of the risk group, determinants of homeostasis disturbances in preeclampsia were characterized, a degree of the microhaemodynamics disturbance in the uterine and placental basins and in the foetus depending upon the degree of preeclampsia severity was found out, differential-diagnostic criteria of the intrauterine foetus state depending upon the severity of homeostatic and microhaemodynamic disturbances in cases of preeclampsia in the risk group pregnant women were established, it was proved that the use of the suggested medical complex improved the state of the risk group pregnant women depending upon the severity of preeclampsia, expert systems were devised in order to prognosticate a possible development of preeclampsia and the degree of its severity. Novelty: for the first time, on the grounds of the conducted complex clinical-laboratory, supersonic and dopplerometrical examination, peculiarities in the course of preeclampsia in the risk group pregnant women at the modern stage were revealed, determinants of homeostasis disturbances were characterized, degrees of the microhaemodynamics disturbance in the uterine and placental basins and in the foetus depending upon the degree of preeclampsia severity were found out. For the first time, differential-diagnostic criteria of the intrauterine foetus state and complex treatment of preeclampsia in the risk group pregnant women were developed. For the first time, methods of preeclampsia prophylaxis in the risk group pregnant women depending upon the severity of homeostatic and nicrohaemodynamic indices were grounded, expert systems for prognosticating a possible development of preeclampsia and the degree of its severity were devised. Degree of introduction: results of the thesis were introduced into medical and diagnostic institutions of the City of Kharkiv (municipal health care establishments: maternity homes Nos 1, 2, 5 and 7, Kharkiv Regional Hospital). Sphere of application: medicine, obstetrics and gynaecology.