Ratushnyak N. Immunologic chsnges in patients with ischemic heart desease and essential hypertension and their correction by atorvastatin

The dissertation is devoted to assessment of the features of immune status in patients with ischemic heart disease and essential hypertension. TNF-б, ІL-1 , ІL-10, CD3+, CD4+, CD8+, monocytes phagocyte index (30 and 120), circulating immune complexes and C-reactive protein blood levels were determined. An-other purpose of the study was to establish atorvastatin influence on immune status in patients with ischemic heart disease accompanied by essential hyper-tension. After examination of 110 patients were detected that pro-inflammatory cytokines serum levels were significantly higher in patients with hypertension combined with ischemic heart disease (acute coronary syndrome or angina pec-toris). It was established that adequate antihypertensive and antianginal treat-ment with atorvastatin during 6 months significantly influence cellular immu-nity (increasing lymphocytes level, predominantly CD4+ T- lymphocytes, and phagocytes activity), decreases serum blood level of circulating immune com-plexes, pro-inflammatory cytokines (IL-1в, TNF-б) and increases serum blood level of anti-inflammatory cytokines (IL-10).