Boykiv A. The course of adrenalin myocardiopathy in case of different types of inflammatory reaction

This thesis is devoted to the study of the peculiarities of necrotic process development in myocardium caused by adrenalin depending on the type of inflammatory reaction. It has been established that the development of adrenalin myocardiopathy is accompanied by the elevation of transaminases activity, concentration of lipid peroxidation metabolites, medium molecular weight blood peptides, immunoglobulins, circulating immune complexes, absorption capability of erythrocytes and number of leucocytes in rats’ blood. At early stages of observation (1 hour after adrenalin injection) established changes are the most intensive in case of hyperergic course of inflammatory reaction, and at far-off stages (7 days) – in case of hypoergic one. Development of adrenalin myocardiopathy is accompanied by disturbance of structural and ultra structural organization in ventricles’ myocardium. The signs of cardiomyocytes lesion increase during 24 hour and are more intensive in case of hyperergic type of inflammation. The process of myocardium restoring (7th day after adrenalin injection) in case of changed reactivity is disturbed. In case of hypoergic type of inflammatory reaction this disturbance is confirmed by focal destruction of muscular fibers. In case of hyperergic type of inflammatory reaction this disturbance is confirmed by domination of acute blood disorders in small vessels, appearance of new areas of necrosis. Volume percentage of damaged cardiomyocytes during 1 and 24 hours of adrenalin myocardiopathy manifestation is the highest in case of hyperergic type of inflammatory reaction and on 7th day – in case of hypoergic one.