Volikov I. Choice of preemptive analgesia method in elderly people undergoing abdominal surgery

Dissertation is devoted to the assessment of initial state of the hemodynamic, epinephrine, gystamine and serotonin in elderly patients with diseases of gastrointestinal organs, to efficacy of different preemptive analgesia methods with use of diclofenac, magnesium sulfate and parecoxib. It was revealed that the use of the patient control analgesia is not enough to control postoperative pain syndrome and leads to deterioration of hemodynamic and homeostasis systems. Preemptive analgesia with diclofenac leads to decrease of the postoperative pain syndrome on 12-26 %, of the using of non-steroid anti-inflammatory drugs on 9-41 %, opioid drugs on 26-30 %, improves blood pressure and stroke volume on 5-15 % and does not increase activity of epinephrine, gystamine and serotonin systems. Preemptive analgesia with magnesium sulfate leads to decrease of the postoperative pain syndrome on 6-40 %, of the using of non-steroid anti-inflammatory drugs on 26-34 %, opioid drugs on 17-61 %, improves blood pressure and stroke volume on 5-20 % and stabilizes epinephrine, gystamine and serotonin systems. Preemptive analgesia and postoperative analgesia with parecoxib leads to decrease of the postoperative pain on 17-50 %, refuse of using opioid drugs on 90 % patients, improves blood pressure and stroke volume on 5-25 %.