Shylin S. Amino acides and peptides derivatives of coumarins

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U004062

Thesis Registration Form

0409U004062.pdf

Applicant for

Shylin Sergiy Volodimirovich

Specialization

02.00.10 - Біоорганічна хімія

Date of defense

16-06-2009

Specialized Academic Board

Д 26.001.25

Taras Shevchenko National University of Kyiv

Essay

Coumarins with different substituents in 3,4,5,7,8 positions of coumarin ring were synthesized. Their further chemical modification was achieved, and amino acid or peptide derivatives of the coumarin were obtained by such procedures: 1) C-aminomethylation of 7-hydroxycoumarins with amino acids and formaldehyde; 2) acylation of 7-hydroxycoumarins with symmetric anhydrides of Boc-amino acids; 3) condensation of amino acids with coumarins or furocoumarins containing the HOOC-group. Amides which based on conformationally constrained 10-hydroxydecahydroisocoumarin and amino acid derivatives of coumarin were also synthesized. Structure of synthesized compounds was studied by the NMR- IR- and UV-spectroscopy.

Thesis supervisor

Khilya Vladimir Petrovich

Official opponents

Бальон Ярослав Григорович
Смолій Олег Борисович

Files

DiserShylin.doc

aref.doc

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