Chemerys M. Peculiarities of toxicosis formation and explanation of detoxications method and organ-protective therapy for patients with toxicodermia

Dissertation is dedicated to study of indices of functional state of some homeostasis systems in patients with toxicodermia and principal factors influencing upon this state, research of system-organ disfunctions and reasons for their occurrence and development, toxemia parameters of patients with skin toxic affection, study of peculiarities of toxicosis onset in patients depending on nosological form, toxicormias etiological factor. For the first time the mechanism of endotoxemia development in patients with toxicodermia was examined. Basing on the received data of toxicometric examinations for the first time reasonability of differentiated approach application while determining detoxication therapy methods selection was explained. Basing on the received data of toxicometric examinations for the first time reasonability of plasmapheresis while multimodality treatment of patients with grave progress of skin toxic affections was explained. For the first time high efficiency of plasmapheresis while treatment of patients with grave toxicodermia progress was examined and established. Safety of used therapeutic plasmapheresis was proved.