Kolianchuk Y. Reproductive toxicity of generic substances of synthetic pyrethroid lambda-cyhalothrin for Wistar hannover rats when exposed during gametogenesis

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0420U000081

Thesis Registration Form

0420U000081.pdf

Applicant for

Specialization

  • 14.03.06 - Токсикологія

23-06-2020

Specialized Academic Board

Д 26.630.01

Essay

The dissertation is devoted to the study of the reproductive function state by the experiment on rats after exposure with synthetic pyrethroid lambda-cyhalothrin (LCT) during gametogenesis. It has been shown that LCT disrupts the reproductive function of male and female rats. It was shown that the synthetic pyrethroid lambda-cyhalothrin demonstrated endocrine-disruptive properties, which were typical for irreversible xenoagonists of estrogen receptors with a medium degree of activity, caused antiandrogenic effect, and changed the testosterone level in blood serum of experimental animals. In the range of studied doses, the no-observed-effect-level (NOAEL) of LCT for reproductive toxicity was established - 0.3 mg/kg of body weight.

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