The dissertation is devoted to the determination of influence of dialysis technologies on character of trace elements disorders and the endotoxemia parameters in chronic kidney disease V D stage patients. In chronic kidney disease V D stage patients different factors affect whole blood and serum concentrations of trace elements like increased oral intake, failure of renal excretion, degree of renal failure and metabolic alterations associated with renal failure. We found that the chronic kidney disease V D in children and adult patients is accompanied by significant changes of trace elements level in blood. In adults with chronic kidney disease V D the blood level of aluminum, cadmium, chromium, strontium, barium, beryllium, lead, manganese, zinc were increased; selenium - decreased in comparison with control. In children with chronic kidney disease V D the blood levels of aluminum, cadmium, chromium, strontium, nickel, lead were increased; zinc, arsenic, barium, rubidium, cesium - were decreased in comparison with control. In both adults and children with chronic kidney disease V D aluminum, cadmium, chromium, strontium were increased and exceed normal physiological values. Besides, we determined that the disease is accompanied by a signs of severe endotoxemia, that due to the preferential accumulation of free circulated endotoxins with particle size of 10-200 nm in the bloodstream. The using of hemodialysis is accompanied by elimination from the bloodstream of rubidium, strontium and accumulation of aluminum and cadmium. The using of hemodiafiltration leads to decreasing of cesium, arsenic and barium levels. So, there were concluded that using of hemodiafiltration is more preferable in chronic kidney disease V D patients with high aluminum and cadmium levels. Based on the findings of correlations between the whole bloods trace element content and clinical and laboratory parameters it was substantiated correction criteria of trace element content disorders. In patients exceed 75 percentile of concentration of aluminum the hemoglobin level decreasing; cadmium - alpha amylase activity increasing; chromium, strontium - leukocytes quantity increasing was observed. So, clinical-laboratory changes took places in chronic kidney disease V D patients with elevated blood level of aluminum - 0,306 mg/dm3, cadmium - 0,002 mg/dm3, chromium - 0,228 mg/dm3, strontium - 0,047 mg/dm3 and aluminum / zinc ratio - higher than 0,0037. These measures should be used as threshold trace elements doses for correction therapy administration in chronic kidney disease V D patients.
